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known when the number and location of disul de bridges involving cysteine residues have been determined. This is especially important for proteins normally secreted from their cells of origin (e.g. hormones, immunoglobulins). Disul de bridges are used to stabilize otherwise unstable structures and also represent important intermediates in the folding pathways of such proteins. In addition, the disul de bridged polypeptide is an oxidized form of the protein which is appropriate to the oxidizing nature of the extracellular environment. Indeed, in protein engineering, disul de bridges are frequently introduced into proteins to enhance their stability to heat (e.g. in the design of enzymes suitable for enantioselective synthesis).

As a sign of progress in nanotechnology, IBM scientists recently announced that they have created an embryonic nanoprocessor using a single carbonnanotube molecule and a standard semiconductor processes The circuit, called a ring oscillator, consists of 12 eld-effect transistors laid along a carbon nanotube 18 mm long, which is about one- fth the width of a human hair Clearly, it is far from molecular sized, but remember, this is only the beginning The direction being pursued is to make circuits faster and compatible with regular silicon technology for everyday integrated circuits At the molecular level, random thermal activity would be quite rough on rigid technology, so exible wet technology must be considered In the context of watery technology, it is conceivable that imitation neurons might someday replace damaged biological nerve connections This is not a surprising concept in view of successes in brain machine interfacing.

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With laser light the design of the interferometer is greatly simpli ed, but some new problems are introduced. The main problem is the presence of many spurious fringes over the desired interference pattern due to re ections on lens surfaces and glass plates. All re ections produce interference fringes because of the long coherence length of laser light. Probably the rst laser radial shear interferometer was designed by Som (1970); it is illustrated in Figure 5.17. There is, however, a great problem with this design since the virtual points of divergence P1 and P2 for the two wave-fronts do not coincide, as pointed out by Murty and Shukla (1973). Hence, a perfect system produces a system of concentric circular fringes, similar to Newton rings, and it is dif cult to analyze the interferogram with this as a reference. Murty points out that for easier analysis a perfect optical system under test must give either a fringe-free eld or a set of straight fringes. To eliminate this problem, Murty and Shukla (1973) modi ed Som s design and proposed the interferometer shown in Figure 5.18, in which one of the re ecting surfaces is spherical. If a and b are the distances from the concave and plane mirrors, repectively, to the center of the beam-dividing surface, the radius of curvature r of the re ecting surface must be r 2b a a : b a 5:16

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Neuroscientists have signi cantly advanced brain machine interface technology, to the point where severely handicapped people who cannot contract even one leg or arm muscle can now compose and send e-mails independently and operate a television set They are using only their thoughts to execute these actions One day these and other handicapped persons may be able to feed themselves with a robotic hand that moves according to their mental commands The hope is that imitation neurons might enable the muscles of the paralyzed to be useful again Arti cial Neural Networks Arti cial neural networks are based on arti cial neurons, each of which is composed of a weighted sum and a comparator, giving a true or a false output An arti cial neural network can be taught to recognize important patterns in a large eld of data using an iterative algorithm to design the weights.

T h e reader will soon realize that the arguments that are used in the sequel in order to arrive at the nonstationary EMSE, starting from the variance relation (20.32), are almost identical to the arguments used before in s 16-19 while studying the stationary EMSE of several adaptive filters. For this reason, the derivations here are brief.

1.5.1 The Worldwide Web The worldwide web was originally devised as a distributed computer network for the military capable of withstanding nuclear attack! In the last decade, it has grown to include

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